I've tried CleanMem, and it definitely works for me. It has saved me 200-300 mb of my memory when idle, mainly because A-squared hogs around 100 mb.
Even though I have 4 gb of RAM (actually 2 gb, 1 gb lost to 32-bit, another used for Eboostr cache), I still use it.
Also I have 50 different processes (including Firefox with 33 add-ons) running, but only 450 mb of RAM are being used overall (mostly by the Windows XP OS). If I exclude Firefox 350 mb.
My gaming speed has never lagged, even though CleanMem is scheduled to run every 15 min.
There is absolutely no loss of performance only gains. If you find that wasting an extra 200-300mb of RAM is more worth it than 300kb of disk space and less than a minute of your time, so be it.
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